Fig. 5
From: Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer
GSEA reveals potential downstream signaling of CENPF. GSEA results showed that the cell cycle (a), P53 signaling pathways (b), PI3K/AKT/mTOR signaling (c), and mTORC1 pathways (d) were enriched in the high CENPF expression group. Top panels indicate the enrichment scores for each gene. Bottom panels show the ranking metrics of each gene. Y-axis: ranking metric values; X-axis: ranks for all genes. NES: normalized enrichment score. CENPF silencing reduced the expression of AKT, p-AKT, mTOR, p-MTOR and PTHrP as assessed by western blot analysis (e)