Fig. 6From: Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancerCENPF regulates PI3K/AKT/MTORC1 signaling in BC bone metastasis. In BC cells, CENPF activates PI3K/AKT/mTORC1 signaling resulting in increased PTHrP secretion. This modifies the host osseous environment to promote osteoclast formation and bone colonizationBack to article page