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Table 1 Features and immunoprofile of the published case reports

From: Why are olfactory ensheathing cell tumors so rare?

Sex/age Symptoms Location Enhancement Tumour features Pathology Outcome Marker profile Reference
Female 31 Right-sided anosmia, generalised seizures Anterior cranial fossa, attached to the olfactory groove Heterogeneous Irregular, avascular, cystic-solid, capsulated tumour with calcified nodules. 6.5 cm diameter. Bone erosion Spindle-shaped cells in a wavy cellular arrangement. Distorted and twisted nuclei Complete removal. Uneventful S100 +
EMA −
Leu7 −
[5]
Male
42
Normal olfactory function,
generalised seizures
Anterior cranial fossa (left subfrontal region), arising from the left olfactory bulb Heterogeneous Round, cystic-solid fibrous tumour Spindle-shaped cells, fibrous cords. Curved vesicular nuclei with ill-defined cytoplasmic margins Complete removal. Uneventful S100 +
EMA –
GFAP –
SMA –
Leu7 –
[57]
Male
32
Olfactory function not mentioned, seizures Anterior cranial fossa (left frontal base) Heterogeneous Round, solid, greyish-white tumour with a glistening appearance and rubbery consistency. 3.6 × 3.3 × 3.9 cm Spindle-shaped cells, fibrous cords. Ovoid, elongated, normochromatic, comma-shaped nuclei.
Interrupted deposits of basal lamina in the cellular membrane
Complete removal. Uneventful. S100 + (80% of cells)
Leu7 –
Calretinin – Podoplanin –
EMA –
GFAP –
[58]
Female 28 Anosmia, focal seizures Anterior cranial fossa Heterogeneous Greyish-white, irregular, cloudy, solid. 4 × 3.5 × 2.5 cm Well-circumscribed tumour with elongated spindle-shaped cells, fibrous cords. Moderate nuclear pleomorphism Complete removal. Anosmia S100 +
Synaptophysin +
EMA –
Leu7 –
[56]
Female 30 Right-sided anosmia, headache Anterior cranial fossa, intradural, extra-axial space and attached to the right cribriform plate Homogenous Round, solid 4 cm diameter. Cells formed patterns of compact fascicular Antoni A areas (resembling Schwannoma) with palisading nuclei Complete removal. Olfactory function was not restored S100 +
EMA –
Leu7 –
[63]
Female
41
Anosmia, headache Olfactory mucosa; olfactory cleft extending superiorly to the olfactory groove Heterogeneous Irregular, cystic tumour. Bone defect in the skull base Spindle-shaped cells with eosinophilic cytoplasm and elongated or wavy nuclei with occasional symplastic changes Subtotal resection. Uneventful S100 +
Neuron-specific enolase +
Synaptophysin + (weakly)
EMA –
Leu7 –
[64]
Male
49
Hyposmia, visual impairment Anterior cranial fossa Homogenous Round, cystic-solid tumour, eroding the right cribriform plate Unknown Complete removal. Uneventful S100 +
EMA –
Leu7 –
[55]
Male
20
Normal olfaction, headache, generalized seizures Anterior cranial fossa Heterogeneous The tumour grew towards the left olfactory groove and compressed the left frontal cortex. Greyish-red, vascular tumour. Cystic necrosis inside the tumour. 3.4 × 2.6 × 5.0 cm Spindle-shaped cells were predominantly arranged in compact fascicles or fibrous cords and a few cells were arranged in whorls Complete removal, hyposmia Vimentin +
S100 +
EMA –
Leu7 –
[60]
Female
45
Olfactory function not mentioned, foreign body sensation Anterior cranial fossa. Heterogeneous Irregular, cystic tumour
6.2 × 6.0 × 4.0 cm
Spindle-shaped cells. Compact, fascicular Antoni A areas as well as Antoni B areas Complete removal. Uneventful S100 +
Leu7 –
GFAP –
EMA –
[61]
Female
34
Hyposmia, dizziness,
emotional lability
Anterior cranial fossa Homogenous Well-defined cystic, greyish-red mass, 3.1 cm diameter Spindle cells with eosinophilic protoplasm, tadpole-shaped nucleus Complete removal. Uneventful Vimentin +
S100 +
EMA –
GFAP –
Leu7 –
[59]
Female
40
Left-sided anosmia, migraine, headaches Anterior cranial fossa, olfactory groove adjacent to the left inferior anterior frontal lobe Heterogeneous 3.2 cm diameter Spindle cell neoplasm characterized by extensive palisading and prominent Antoni A (Verocay bodies) and Antoni B areas Complete removal.
Left-sided anosmia
S100 +
Type IV collagen +
Leu7 –
EMA –
[62]
  1. +: positive; cell is expressing marker; –: negative; cell is not expressing marker; S100: S100 protein (glial marker); Leu7 (CD57 or HNK-1): suggested marker for Schwann cells but not OECs; EMA: Epithelial membrane antigen; GFAP: Glial fibrillary acidic protein; SMA: Smooth muscle actin