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Fig. 2 | Cancer Cell International

Fig. 2

From: Long non-coding RNA HOTAIR functions as a competitive endogenous RNA to regulate PRAF2 expression by sponging miR-326 in cutaneous squamous cell carcinoma

Fig. 2

Regulatory effects of HOTAIR on cell migration and progression of CSCC cells. a, b Transwell assay shows the migration of A431 transfected with HOTAIR siRNAs and SCL-1 transfected with HOTAIR OE plasmids. Images are harvested under a light microscope (×200). c, d Wound healing assay shows the migration of A431 transfected with HOTAIR siRNAs and SCL-1 transfected with HOTAIR OE plasmids. e Transfection with HOTAIR siRNAs in A431 promotes the expression of E-cadherin and inhibited the expressions of N-cadherin, Twist, Snail1 and ZEB1. Transfection with HOTAIR OE plasmids in SCL-1 represses the expression of E-cadherin and promotes N-cadherin and Twist expressions. Data are presented as mean ± SD. *P < 0.05; siRNA NC, siRNA negative control group; vector, overexpression plasmid vector negative control group

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Cancer Cell International

ISSN: 1475-2867

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