A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer

Table 2 Association between the plasma circRNA expression levels and clinicopathological characteristics of CRC

Patients	n = 156	Hsa_circ_0082182			Hsa_circ_0000370			Hsa_circ_0035445
Patients	n = 156	Low (n = 52)	High (n = 104)	P-value	Low (n = 64)	High (n = 92)	P-value	Low (n = 113)	High (n = 43)	P-value
Age (years)				0.257			0.255			0.752
< 55	73	21	52		31	32		52	21
≥ 55	83	31	52		33	50		61	22
Gender				0.207			0.061			0.694
Female	91	34	57		43	48		67	24
Male	65	18	47		21	44		46	19
Tumor size				0.087			0.278			0.994
≤ 5	87	34	53		39	48		63	24
> 5	69	18	51		25	44		50	19
Depth of invasion				0.952			0.377			0.061
T1	66	22	44		29	37		53	13
T2	48	17	31		20	28		28	20
T3	24	8	16		11	13		19	5
T4	18	5	13		4	14		13	5
Lymph node metastasis				0.004**			0.014*			0.106
No	89	38	51		42	47		60	29
Yes	67	14	53		22	55		53	14
TNM stage				0.308			0.293			0.023*
I	75	22	53		34	41		48	27
II and III and IV	81	30	51		30	51		65	16

ISSN: 1475-2867