Skip to main content
Fig. 1 | Cancer Cell International

Fig. 1

From: Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma

Fig. 1

Volcano plot of differentially expressed genes in CCAT1-ko cells and expression profiling of CCAT1, cMYC and PRKCQ-AS1 in patient samples. a Volcano plot of differentially expressed genes (p < 0.001) in CCAT1-wt and CCAT1-ko HT-29 colorectal adenocarcinoma cells. The horizontal axis shows the log2 fold up-regulation (to the right) and down-regulation (to the left) in the expression of genes between CCAT1-wt and CCAT1-ko HT-29 cells. The vertical axis demonstrates negative log10 of the p-value of Fisher’s exact test. Each gene is represented by one circle on the graph. Red circles represent genes that are significantly de-regulated. b Quantified expression of CCAT1 (left panel) and cMYC (right panel) in the polyp/tumoral tissue in comparison with normal tissue in patients with low-grade adenoma, advanced adenoma, and adenocarcinoma. c Expression profiling of PRKCQ-AS1 in the polyp/tumoral tissue in comparison with normal tissue in patients with low-grade adenoma, advanced adenoma, and adenocarcinoma. Relative expression levels were determined by Pfaffl analysis, using beta-actin as a reference gene. The statistical analysis between the level of expression of each polyp/tumoral tissue and its adjacent normal mucosa was performed with Mann–Whitney test at significance levels of p < 0.05 (*), p < 0.01 (**), p < 0.001 (***)

Back to article page