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Fig. 5 | Cancer Cell International

Fig. 5

From: RETRACTED ARTICLE: Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT

Fig. 5

TRIM11 interacted with PHLPP1 and promoted its ubiquitination in chordoma cells. a The relative mRNA level of PHLPP1 showed no significant difference between siNC and siTRIM11 transfected cells. b The relative protein level of PHLPP1 was upregulated in siTRIM11 transfected cells, ***p < 0.001 vs siNC. c TRIM11 interacted with PHLPP1 in chordoma cells. d The protein content of PHLPP1 was improved by the proteasome inhibitor MG132, ***p < 0.001 vs siNC, ##p < 0.01 vs siTRIM11, ###p < 0.001 vs siTRIM11. e The ubiquitination of PHLPP1 was reduced in siTRIM11 transfected cells

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Cancer Cell International

ISSN: 1475-2867

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