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Fig. 9 | Cancer Cell International

Fig. 9

From: LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p

Fig. 9

LncRNA-LET inhibits tumor growth in vivo. 786-O cell xenograft tumors stably transfected with lncRNA-LET or EV vectors, as well as 769-P cell xenograft tumors stably transfected with lncRNA-LET shRNA or shRNA Ctrl vectors were obtained. The size of the tumor was then recorded every 3 days for 21 days. Finally, the mice were sacrificed, and tumor tissues were (a) took pictures. b The volume of tumor tissues were measured by caliper and then calculated. c Cell apoptosis and necrosis from tumor tissues was analyzed using HE staining. Scale bars, 100 μm. d Cell apoptosis in tumor tissues was detected through TUNEL staining. Scale bars, 50 μm. e A representative Ki67 immunofluorescence in tumor tissues was explored. Scale bars, 50 μm. n = 6, ##p < 0.01. ccRCC clear cell renal cell carcinoma, lncRNA-LET lncRNA-LET overexpression, EV lncRNA-LET overexpression matched control, lncRNA-LET shRNA lncRNA-LET knockdown, shRNA Ctrl lncRNA-LET knockdown control

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