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Fig. 3 | Cancer Cell International

Fig. 3

From: Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway

Fig. 3

miR-337-3p was the target gene of Circ_ZNF124 in NSCLC. a Predicted binding site of miR-337-3p in Circ_ZNF124. b qRT-PCR detect miR-337-3p and Circ_ZNF124 expression after RNA pull down with AGO2 antibody in A549 cell line. c schematic graph of wild type and mutated miR-337-3p binding sites in Circ_ZNF124. d Pull down miR-337-3p with biotin-labeled wild type Circ_ZNF124 or miR-337-3p binding sites mutated Circ_ZNF124 from A549 cell lysates. e Reporter assay to detect wild type or miR-337-3p binding sites mutated Circ_ZNF124 activity in A549 cell line. NC negative controls.*P < 0.05, **P < 0.01

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