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Fig. 5 | Cancer Cell International

Fig. 5

From: Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway

Fig. 5

JAK2 is a target of miR-337-3p in NSCLC. a Predicated binding site of miR-337-3p in JAK2 3′UTR. b Western blots detect JAK2 expression, GAPDH was used as a loading control. c CRISPR-cas9 mediated JAK2 depletion impaired A549 and H1975 cells viability. d Western blots results of JAK2 deletion. e Western blots detect JAK2 expression after over-expressing miR-337-3p in A549 and H1975. f Luciferase assay results of wild type (WT) JAK2 3′UTR or presumably miR-337-3p binding site mutated JAK2 3′UTR activity in the presence or absence of miR-337-3p mimic in A549

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