Fig. 6

Circ_ZNF124 rescued JAK2/STAT3 signaling pathway activity by acting as miR-337-3p sponge. a Luciferase assay results of JAK2 3′UTR activity. b miR-337-3p inhibitor rescued JAK2 and STAT3 expression induced by miR-337-3p. c Circ_ZNF124 recovered miR-337-3p down-regulated JAK2 and STAT3 protein level. GAPDH was used as loading control. JAK2/STAT3 downstream genes d HIF1a, e c-Fos and f BCL2 expression after over-expression of miR-337-3p mimic in the presence or absence of Circ_ZNF124