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Table 3 Associations between serum vitamin B2 and B12 levels and risk of EPL and ESCC

From: MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

 Quartile
Q1Q2Q3Q4
Esophageal precancerous lesions
 Vitamin B2
  Concentration range, μg/l< 2074.392074.39–2592.692592.69–3019.57> 3019.57
  No. of cases/controls67/5068/5043/5022/50
  Adjusted OR (95% CI)a1.00 (reference)0.62 (0.34–1.13)0.64 (0.35–1.16)0.24 (0.11–0.51)
  p value 0.1210.140< 0.001
 Vitamin B12
  Concentration range, ng/l< 375.09375.09–499.07499.07–570.88> 570.88
  No. of cases/controls53/5068/5021/5058/50
  Adjusted OR (95% CI)a1.00 (reference)1.01 (0.53–1.91)0.54 (0.26–1.13)1.32 (0.70–2.49)
  p value 0.9800.1040.396
Esophageal squamous cell carcinoma
 Vitamin B2
  Concentration range, μg/l< 2074.392074.39–2592.692592.69–3019.57> 3019.57 
  No. of cases/controls51/50104/5037/508/50
  Adjusted OR (95% CI)a1.00 (reference)1.90 (1.10–3.26)0.75 (0.41–1.37)0.19 (0.08–0.44)
  p value 0.0210.345< 0.001
 Vitamin B12
  Concentration range, ng/l< 375.09375.09–499.07499.07–570.88> 570.88
  No. of cases/controls49/50115/5027/509/50
  Adjusted OR (95% CI)a1.00 (reference)1.87 (1.08–3.24)0.55 (0.28–1.05)0.18 (0.07–0.42)
  p value 0.0250.071< 0.001
  1. aAdjusted for gender, age, tobacco smoking and alcoholic drinking