Table 3 Associations between serum vitamin B₂ and B₁₂ levels and risk of EPL and ESCC

Esophageal precancerous lesions

 Vitamin B₂

  Concentration range, μg/l

< 2074.39

2074.39–2592.69

2592.69–3019.57

> 3019.57

  No. of cases/controls

67/50

68/50

43/50

22/50

  Adjusted OR (95% CI)^a

1.00 (reference)

0.62 (0.34–1.13)

0.64 (0.35–1.16)

0.24 (0.11–0.51)

  p value

0.121

0.140

< 0.001

 Vitamin B₁₂

  Concentration range, ng/l

< 375.09

375.09–499.07

499.07–570.88

> 570.88

  No. of cases/controls

53/50

68/50

21/50

58/50

  Adjusted OR (95% CI)^a

1.00 (reference)

1.01 (0.53–1.91)

0.54 (0.26–1.13)

1.32 (0.70–2.49)

  p value

0.980

0.104

0.396

Esophageal squamous cell carcinoma

 Vitamin B₂

  Concentration range, μg/l

< 2074.39

2074.39–2592.69

2592.69–3019.57

> 3019.57

  No. of cases/controls

51/50

104/50

37/50

8/50

  Adjusted OR (95% CI)^a

1.00 (reference)

1.90 (1.10–3.26)

0.75 (0.41–1.37)

0.19 (0.08–0.44)

  p value

0.021

0.345

< 0.001

 Vitamin B₁₂

  Concentration range, ng/l

< 375.09

375.09–499.07

499.07–570.88

> 570.88

  No. of cases/controls

49/50

115/50

27/50

9/50

  Adjusted OR (95% CI)^a

1.00 (reference)

1.87 (1.08–3.24)

0.55 (0.28–1.05)

0.18 (0.07–0.42)

  p value

0.025

0.071

< 0.001