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Table 4 Genotype and allele frequencies for the MTHFR C677T polymorphism and DNA methylation in EPL cases, ESCC cases and healthy controls

From: MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

VariablesControl
n (%)
EPLESCC
n (%)OR (95% CI)p valuen (%)OR (95% CI)p value
MTHFR C677T
 CC99 (49.5)85 (42.5)1.00 84 (42.0)1.00 
 CT82 (41.0)80 (40.0)1.14 (0.74–1.73)0.5597 (48.5)1.39 (0.92–2.11)0.12
 TT19 (9.5)35 (17.5)2.15 (1.14–4.03)0.0219 (9.5)1.18 (0.59–2.37)0.65
 C280 (70.0)250 (62.5)1.00 265 (66.3)1.00 
 T120 (30.0)150 (37.5)1.40 (1.04–1.89)0.03135 (33.8)1.19 (0.88–1.60)0.26
DNA methylation
 p16 methylation70 (35.0)92 (46.0)1.58 (1.06–2.37)0.03126 (63.0)3.16 (2.10–4.76)< 0.01
 p53 methylation74 (36.5)84 (42.0)1.23 (0.83–1.84)0.36113 (56.5)2.21 (1.48–3.30)< 0.01