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Table 4 Genotype and allele frequencies for the MTHFR C677T polymorphism and DNA methylation in EPL cases, ESCC cases and healthy controls

From: MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

Variables

Control

n (%)

EPL

ESCC

n (%)

OR (95% CI)

p value

n (%)

OR (95% CI)

p value

MTHFR C677T

 CC

99 (49.5)

85 (42.5)

1.00

 

84 (42.0)

1.00

 

 CT

82 (41.0)

80 (40.0)

1.14 (0.74–1.73)

0.55

97 (48.5)

1.39 (0.92–2.11)

0.12

 TT

19 (9.5)

35 (17.5)

2.15 (1.14–4.03)

0.02

19 (9.5)

1.18 (0.59–2.37)

0.65

 C

280 (70.0)

250 (62.5)

1.00

 

265 (66.3)

1.00

 

 T

120 (30.0)

150 (37.5)

1.40 (1.04–1.89)

0.03

135 (33.8)

1.19 (0.88–1.60)

0.26

DNA methylation

 p16 methylation

70 (35.0)

92 (46.0)

1.58 (1.06–2.37)

0.03

126 (63.0)

3.16 (2.10–4.76)

< 0.01

 p53 methylation

74 (36.5)

84 (42.0)

1.23 (0.83–1.84)

0.36

113 (56.5)

2.21 (1.48–3.30)

< 0.01