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Table 7 Association between DNA methylation with the MTHFR C677T genotype and the risk of EPL and ESCC

From: MTHFR C677T genetic polymorphism in combination with serum vitamin B2, B12 and aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and esophageal precancerous lesions: a case–control study

DNA methylationEPL [OR (95% CI)a, p for interaction]ESCC [OR (95% CI)a, p for interaction]
CCCTTTCCCTTT
p16U1.00 (reference)0.88 (0.50–1.53)
0.640
1.32 (0.62–2.80)
0.474
1.00 (reference)1.03 (0.56–1.90)
0.921
0.66 (0.25–1.77)
0.409
p16 M1.04 (0.58–1.85)
0.900
1.98 (1.01–3.89)
0.048
17.79 (2.26–140.22)
0.006
1.91 (1.95–3.47)
0.033
4.86 (2.48–9.50)
< 0.001
20.40 (2.53–164.81)
0.005
p53U1.00 (reference)0.90 (0.46–1.40)
0.441
1.25 (0.59–2.63)
0.558
1.00 (reference)0.90 (0.50–1.60)
0.710
0.49 (0.19–1.31)
0.156
p53 M0.77(0.43–1.37)
0.369
1.56(0.79–3.09)
0.205
13.28(1.67–105.70)
0.015
1.15(0.64–2.06)
0.643
3.27(1.68–6.34)
< 0.001
15.24(1.90–122.62)
0.010
  1. U unmethylated, M methylated
  2. aAdjusted for gender, age, tobacco smoking and alcoholic drinking