Table 7 Association between DNA methylation with the MTHFR C677T genotype and the risk of EPL and ESCC
DNA methylation | EPL [OR (95% CI)a, p for interaction] | ESCC [OR (95% CI)a, p for interaction] | ||||
|---|---|---|---|---|---|---|
CC | CT | TT | CC | CT | TT | |
p16U | 1.00 (reference) | 0.88 (0.50–1.53) 0.640 | 1.32 (0.62–2.80) 0.474 | 1.00 (reference) | 1.03 (0.56–1.90) 0.921 | 0.66 (0.25–1.77) 0.409 |
p16 M | 1.04 (0.58–1.85) 0.900 | 1.98 (1.01–3.89) 0.048 | 17.79 (2.26–140.22) 0.006 | 1.91 (1.95–3.47) 0.033 | 4.86 (2.48–9.50) < 0.001 | 20.40 (2.53–164.81) 0.005 |
p53U | 1.00 (reference) | 0.90 (0.46–1.40) 0.441 | 1.25 (0.59–2.63) 0.558 | 1.00 (reference) | 0.90 (0.50–1.60) 0.710 | 0.49 (0.19–1.31) 0.156 |
p53 M | 0.77(0.43–1.37) 0.369 | 1.56(0.79–3.09) 0.205 | 13.28(1.67–105.70) 0.015 | 1.15(0.64–2.06) 0.643 | 3.27(1.68–6.34) < 0.001 | 15.24(1.90–122.62) 0.010 |