Skip to main content

Advertisement

Table 1 Correlation between specific fusion transcripts and clinical features of pro-B-ALL

From: Clinical-biological characteristics and treatment outcomes of pediatric pro-B ALL patients enrolled in BCH-2003 and CCLG-2008 protocol: a study of 121 Chinese children

Clinical featuresKMT2A rearrangement (%)BCR-ABL1 (%)ETV6-RUNX1 (%)Pro-B without fusion (%)P
Gender
 Male18 (56)4 (100)0 (0)47 (58)0.074
 Female14 (44)0 (0)3 (100)34 (42)
Age (years)
 < 19 (28)0 (0)0 (0)2 (2)<0.001
 1–1020 (63)2 (50)2 (67)63 (78)
 ≥ 103 (9)2 (50)1 (33)16 (20)
WBC
 < 50 × 109/L16 (50)4 (100)3 (100)60 (74)0.027
 ≥ 50 × 109/L16 (50)0 (0)0 (0)21 (26)
Prednisone response
 Good29 (91)4 (100)3 (100)75 (93)0.835
 Poor3 (9)0 (0)0 (0)6 (7)
MRD at day 33
 < 0.01%10 (37)1 (25)0 (0)15 (24)0.747
 0.01–1%14 (52)2 (50)2 (100)35 (56)
 ≥ 1%3 (11)1 (25)0 (0)12 (19)
MRD at day 78
 < 0.1%22 (81)3 (100)2 (100)51 (86)0.789
 ≥ 0.1%5 (19)0 (0)0 (0)8 (14)
  1. Italic signifies P < 0.05