S1PRs | Cancers |
---|---|
S1PR1 | |
 Promote invasion and angiogenesis [19, 21, 81]  Promote progression [57, 75]  Promote migration and invasion [71,72,73, 76]  Promote invasion [77] | Breast cancer [19, 21, 71,72,73] Mice B16 tumor [75] Colon cancer [57] Wilms tumor [76] Glioblastoma [77] Fibrosarcoma [79] Hodgkin lymphoma [80] |
S1PR2 | |
 Pro-tumorigenesis | |
  Promote growth and invasion [82] | Cholangiocarcinoma [82] |
  Promote angiogenesis and growth [11] | Wilms tumor [11] |
  Promote invasion [83] | Glioma cell U-118 [83] |
  Promote migration and invasion [84] | Pancreatic cancer [84] |
  Promote lung metastasis [85] | Bladder cancer [85] |
Chronic myeloid leukemia [87] | |
 Anti-tumorigenesis | |
  Suppress invasion [90] | Thyroid cancer C643 cells [90] |
  Suppress proliferation [12] | Wilms tumor [12] |
  Lead to diffuse B-cell lymphoma formation [91] | S1PR2 knockout mice [91] |
  Promote invasion [93] | Repress S1PR2 expression in esophageal squamous cell carcinoma [93] |
S1PR3 | |
 Promote migration [98] | Nasopharyngeal carcinoma cells [98] |
 Promote proliferation [102] | Osteosarcoma cells [102] |
S1PR4 | |
S1PR5 | |
 Pro-tumorigenesis | |
  Promote survival [108] | Prostate cancer cells [108] |
Anti-tumorigenesis | |
  Suppress proliferation and migration [109] | Esophageal squamous cell carcinoma cells [109] |