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Table 2 Roles played by individual S1PRs in different cancer

From: Roles of sphingosine-1-phosphate signaling in cancer

S1PRsCancers
S1PR1
 Promote invasion and angiogenesis [19, 21, 81]
 Promote progression [57, 75]
 Promote migration and invasion [71,72,73, 76]
 Promote invasion [77]
 Promote survival and migration [78,79,80]
Breast cancer [19, 21, 71,72,73]
Mice B16 tumor [75]
Colon cancer [57]
Wilms tumor [76]
Glioblastoma [77]
Fibrosarcoma [79]
Hodgkin lymphoma [80]
S1PR2
 Pro-tumorigenesis
  Promote growth and invasion [82]Cholangiocarcinoma [82]
  Promote angiogenesis and growth [11]Wilms tumor [11]
  Promote invasion [83]Glioma cell U-118 [83]
  Promote migration and invasion [84]Pancreatic cancer [84]
  Promote lung metastasis [85]Bladder cancer [85]
  Increase drug resistance [66, 87]Chronic myeloid leukemia [87]
 Anti-tumorigenesis
  Suppress migration [88, 89]Glioblastoma cells [88, 89]
  Suppress invasion [90]Thyroid cancer C643 cells [90]
  Suppress proliferation [12]Wilms tumor [12]
  Lead to diffuse B-cell lymphoma formation [91]S1PR2 knockout mice [91]
  Promote invasion [93]Repress S1PR2 expression in esophageal squamous cell carcinoma [93]
S1PR3
 Promote progression [95,96,97]Breast cancer [95,96,97]
 Promote migration [98]Nasopharyngeal carcinoma cells [98]
 Promote proliferation [102]Osteosarcoma cells [102]
 Promote growth [99,100,101]Human lung adenocarcinoma cells [99,100,101]
S1PR4
 Promote invasion and aggressiveness [105, 106]Breast cancer cells [105, 106]
S1PR5
 Pro-tumorigenesis
  Promote survival [108]Prostate cancer cells [108]
Anti-tumorigenesis
  Suppress proliferation and migration [109]Esophageal squamous cell carcinoma cells [109]