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Table 1 Effects of matrix fixation and NHE1 expression on cell migration and morphology

From: MMP3 activity rather than cortical stiffness determines NHE1-dependent invasiveness of melanoma cells

MatrixNativeFixed
NHE1 expressionMock control (n = 30; N = 5)Overexpressed (n = 40; N = 3)Mock control (n = 40; N = 3)Overexpressed (n = 41; N = 3)
Speed [µm min−1]0.44 ± 0.030.034 ± 0.020.48 ± 0.040.13 ± 0.01
Net distance [µm]61.92 ± 9.4245.17 ± 5.657.92 ± 9.0711.93 ± 2.33
Total distance [µm]130.92 ± 8.61103.12 ± 5.78143.37 ± 10.6737.84 ± 2.83
Directionality0.45 ± 0.050.44 ± 0.040.38 ± 0.040.28 ± 0.04
Structural index0.43 ± 0.030.5 ± 0.020.3 ± 0.010.42 ± 0.02
Area [µm2]888 ± 1121115 ± 841251 ± 781298 ± 94
  1. Data are shown as mean ± SEM For p values and further information, please see text