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Fig. 1 | Cancer Cell International

Fig. 1

From: Abiraterone and MDV3100 inhibits the proliferation and promotes the apoptosis of prostate cancer cells through mitophagy

Fig. 1

Abiraterone and MDV3100 induced mitophagy in LNCaP cells. a Representative micrographs of LNCaP cells transiently transfected with pDsRed-NC expression plasmids. The cells were treated with vehicle alone (control), abiraterone, or MDV3100. b Representative micrographs of green and red channel fluorescence of Mito-Rosella transiently transfected cells following treatments described above for a. The merged panel shows overlap of fluorescence from the pHluorin, DsRed and DAPI. The green/red fluorescence ratio of single cell under the above conditions was quantitatively measured. Error bars represent mean ± S.D. of ratios for n = 25 cells per condition. The experiments were performed three times, and a representative result is shown above; ***p < 0.001 versus control, based on unpaired t-test. NC: normal control; DAPI: 4′,6-diamidino-2-phenylindole

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