Fig. 5

Abiraterone and MDV 3100 mediated cell proliferation and apoptosis in LNCaP cells through regulating mitophagy. a The blockade of mitophagy and abiraterone- and MDV3100-mediated inhibition of proliferation in LNCaP cells. LNCaP cells were treated with mdivi-1 or abiraterone or MDV3100 for 24 h, 48 h and 72 h, respectively. The absorbance values with CCK-8 were detected at 450 nm. Error bars represent mean ± S.D. of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001 versus control, based on t-test. b Representative dot plots of Annexin-V-FITC and PE stained by propidium iodide (PI) in the LNCaP cells following treatments described above for A.MDV3100 Error bars represent mean ± S.D. of three independent experiments, *p < 0.05, **p < 0.01 versus control, based on t-test. Mdivi-1: Mitochondrial division inhibitor 1