Table 2 Univariate and multivariate Cox regression analyses in TCGA cohort
Variables | Patients | Univariable analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | ||
Gender (male/female) | 366/132 | 0.329–1.926 | 0.612 | ||
Age (60 vs. > 60) | 217/281 | 0.978–1.616 | 0.069 | ||
Alcohol (no/yes) | 157/330 | 0.731–1.296 | 0.893 | ||
HPV (no/yes) | 64/19 | 0.622–2.481 | 0.416 | ||
Lymph node neck dissection (yes/no) | 405/90 | 0.971–1.888 | 0.074 | ||
Histologic grade (G1/G2/G3/G4) | 61/297/119/2 | 0.893–1.354 | 0.370 | ||
TNM stage (I/II/III/IV) | 25/70/78/257 | 1.186–1.701 | < 0.001 | 0.805–1.541 | 0.541 |
Lympho-vascular invasion (no/yes) | 218/119 | 1.208–2.384 | 0.002 | 0.588–1.442 | 0.691 |
Perineural invasion present (no/yes) | 186/163 | 1.557–3.116 | < 0.001 | 1.162–2.862 | 0.009 |
Extranodal extension (no/yes) | 290/106 | 1.989–3.716 | < 0.001 | 1.488–3.817 | < 0.001 |
Risk (low-risk/high-risk) | 357/141 | 2.119–3.668 | < 0.001 | 1.182–2.750 | 0.006 |