Table 1 A total of 76 deregulated genes were identified in 1839 primary tumor versus metastatic lymph node genes
Gene symbol | logFC | P value | Hallmark |
|---|---|---|---|
MBL2 | 1.836355 | 0.016409 | ALLOGRAFT_REJECTION |
ITGAL | 1.09615 | 0.029208 | ALLOGRAFT_REJECTION |
CD3G | 1.084988 | 0.023672 | ALLOGRAFT_REJECTION |
FLNA | 1.003019 | 0.037726 | ALLOGRAFT_REJECTION |
GLMN | − 1.11045 | 0.044154 | ALLOGRAFT_REJECTION |
VAV2 | 1.222483 | 0.037575 | ANGIOGENESIS, APICAL_JUNCTION |
ACTA1 | − 4.81243 | 0.007734 | APICAL_JUNCTION |
EFHC1 | − 1.33106 | 0.001242 | BILE_ACID_METABOLISM |
DIO2 | − 1.48714 | 0.003577 | BILE_ACID_METABOLISM |
SMC6 | − 1.01378 | 0.036294 | E2F_TARGETS |
ORC2 | − 1.02171 | 0.039099 | E2F_TARGETS |
LUC7L3 | − 1.21609 | 0.002313 | E2F_TARGETS |
MRE11A | − 1.23003 | 0.045764 | E2F_TARGETS |
ABCA3 | − 1.4387 | 0.009719 | ESTROGEN_RESPONSE_EARLY, ESTROGEN_RESPONSE_LATE |
TTC39A | − 1.90927 | 0.002779 | ESTROGEN_RESPONSE_EARLY |
NPY1R | 2.020464 | 0.03779 | ESTROGEN_RESPONSE_LATE, ESTROGEN_RESPONSE_EARLY |
GAL | 1.468347 | 0.023249 | ESTROGEN_RESPONSE_LATE |
EGR3 | 1.177485 | 0.036595 | ESTROGEN_RESPONSE_LATE, ESTROGEN_RESPONSE_EARLY, KRAS_SIGNALING_UP |
CASC5 | 1.897606 | 0.036429 | G2M_CHECKPOINT |
CASP8AP2 | − 1.09086 | 0.016979 | G2M_CHECKPOINT |
EZH2 | − 1.18721 | 0.018306 | G2M_CHECKPOINT, E2F_TARGETS |
MNAT1 | − 1.27108 | 0.027402 | G2M_CHECKPOINT |
SMC2 | − 1.33982 | 0.04864 | G2M_CHECKPOINT |
SERPINE1 | 1.733088 | 0.021088 | HYPOXIA |
FOS | 1.543577 | 0.005153 | HYPOXIA |
IER3 | 1.387516 | 0.015602 | HYPOXIA, APOPTOSIS |
ANGPTL4 | 1.261686 | 0.018984 | HYPOXIA, KRAS_SIGNALING_UP, ADIPOGENESIS |
SLC2A5 | − 2.14747 | 0.047968 | HYPOXIA |
SOCS3 | 1.72843 | 0.019538 | IL6_JAK_STAT3_SIGNALING |
INHBE | − 1.17054 | 0.031406 | IL6_JAK_STAT4_SIGNALING |
ZNF639 | 2.511151 | 0.001222 | KRAS_SIGNALING_UP |
RBP4 | 2.229625 | 0.033045 | KRAS_SIGNALING_UP |
CD37 | 1.547497 | 0.019287 | KRAS_SIGNALING_UP |
GFPT2 | 1.031506 | 0.042835 | KRAS_SIGNALING_UP |
SLMO2 | − 1.00092 | 0.02985 | KRAS_SIGNALING_UP |
CFH | − 1.6692 | 0.040962 | KRAS_SIGNALING_UP |
SLPI | − 1.67431 | 0.014661 | KRAS_SIGNALING_UP |
BTC | − 2.14105 | 0.00012 | KRAS_SIGNALING_UP |
TMEM158 | − 2.44114 | 0.000586 | KRAS_SIGNALING_UP |
SVIL | − 1.15372 | 0.004237 | MYOGENESIS |
IFRD1 | − 1.29777 | 0.000871 | MYOGENESIS |
AGL | − 1.34563 | 0.006822 | MYOGENESIS |
FABP3 | − 1.39162 | 0.018123 | MYOGENESIS |
CKMT2 | − 1.43326 | 0.0434 | MYOGENESIS |
MYH8 | − 1.48548 | 0.015832 | MYOGENESIS |
DMD | − 1.53731 | 0.006311 | MYOGENESIS, G2M_CHECKPOINT |
MYOZ1 | − 1.74048 | 0.041979 | MYOGENESIS |
CHRNA1 | − 1.8081 | 0.017455 | MYOGENESIS |
HRC | − 2.02106 | 0.038865 | MYOGENESIS |
FHL1 | − 2.03688 | 0.035865 | MYOGENESIS |
SLN | − 2.11469 | 0.041452 | MYOGENESIS |
ACTC1 | − 2.90968 | 0.011697 | MYOGENESIS |
DES | − 3.03388 | 0.031095 | MYOGENESIS |
MYBPH | − 3.21711 | 0.003079 | MYOGENESIS |
TNNT1 | − 3.34517 | 0.024009 | MYOGENESIS |
MYH2 | − 3.3503 | 0.042848 | MYOGENESIS |
MB | − 3.35038 | 0.010556 | MYOGENESIS |
TCAP | − 3.38871 | 0.029364 | MYOGENESIS |
MYLPF | − 3.50266 | 0.020669 | MYOGENESIS |
TNNC2 | − 3.52148 | 0.020435 | MYOGENESIS |
MYL2 | − 3.59938 | 0.011658 | MYOGENESIS |
ACTN2 | − 4.31463 | 0.01354 | MYOGENESIS |
TNNI2 | − 4.42965 | 0.011318 | MYOGENESIS |
MYL1 | − 4.54843 | 0.006995 | MYOGENESIS |
CKM | − 4.71858 | 0.011289 | MYOGENESIS |
TNNI1 | − 4.77636 | 0.0062 | MYOGENESIS |
TNNC1 | − 5.64825 | 0.007417 | MYOGENESIS |
CSRP3 | − 5.77325 | 0.012999 | MYOGENESIS |
PPP2R1B | 1.171797 | 0.042423 | PI3K_AKT_MTOR_SIGNALING |
FGF17 | − 1.34021 | 0.032683 | PI3K_AKT_MTOR_SIGNALING |
IL4 | − 1.52042 | 0.040415 | PI5K_AKT_MTOR_SIGNALING, IL6_JAK_STAT3_SIGNALING |
ADCY2 | − 1.91434 | 0.025949 | PI6K_AKT_MTOR_SIGNALING |
SH3GL2 | 1.508413 | 0.042024 | PROTEIN_SECRETION |
OCRL | − 1.09672 | 0.008807 | PROTEIN_SECRETION |
JUNB | 1.047607 | 0.019591 | REACTIVE_OXIGEN_SPECIES_PATHWAY |
GCLM | − 1.71176 | 0.003821 | REACTIVE_OXIGEN_SPECIES_PATHWAY, BILE_ACID_METABOLISM |