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Fig. 3 | Cancer Cell International

Fig. 3

From: Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies

Fig. 3

Effect on MKN-45 viability of AvIR-PIT. a The relative cell viability of MKN-45 cells was evaluated after AvIR-PIT treatment (3 J/cm2) with various concentrations of Bio-CEA or AvIR by using the CellTiter-Glo reagent. When the dose of Bio-CEA was variable, that of AvIR was constant, and vice versa. b The cell viability after AvIR-mediated PIT with each indicated BioAb was evaluated (left panel). When IR700-anti-CEA was used for cellular targeting, NIR light irradiation (3 J/cm2) was done without adding AvIR as conventional PIT treatment. The data are the means ± SEM (n = 3, *p < 0.05, **p < 0.01 vs. combination therapy using both Bio-CEA and Bio-CD44, one-way ANOVA with Dunnett’s test). Representative dot plot of the FACS analysis for the expression of CEA and CD44 is also shown (right panel)

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