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Fig. 5 | Cancer Cell International

Fig. 5

From: Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

Fig. 5

High mitochondrial mass is associated with increased cellular proliferation and cisplatin resistance. Mito-High: highest 10% of Mito Tracker stained cells; Mito-Low: lowest 10% of Mito Tracker stained cells. Para 3.4: unsorted Para clone cells (the subtype is 3.4). a Absolute cell numbers per well 1 week after cisplatin treatment at the indicated concentrations. b Normalized cell growth based on the cell numbers without cisplatin treatment, i.e. untreated cell numbers (a) were set as 100%. c Absolute colony numbers per well 2 weeks after cisplatin treatment at the indicated concentrations. d Normalized colony formation capacity based on colony numbers without cisplatin treatment, i.e. untreated colony numbers (c) were set as 100%. e Images of colony formation for two populations Mito-High (left) and Mito-Low (right)

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