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Fig. 6 | Cancer Cell International

Fig. 6

From: Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment

Fig. 6

High mitochondrial mass is associated with increased MTA sensitivity. The cell population with high mitochondrial mass is sensitive to pemetrexed (MTA). Mito-High: highest 10% of Mito Tracker stained cells; Mito-Low: lowest 10% of Mito Tracker stained cells. Para 3.4: unsorted Para clone cells (the subtype is 3.4) a Absolute cell numbers per well 1 week after MTA treatment at the indicated concentrations. b Normalized cell growth based on the cell numbers without MTA treatment, i.e. untreated cell numbers (a) were set as 100%. c Absolute colony numbers per well 2 weeks after MTA treatment at the indicated concentrations. d Normalized colony formation capacity based on colony numbers without MTA treatment, i.e. untreated colony numbers (c) were set as 100%. e Images of colony formation assay for the two populations Mito-High (left) and Mito-Low (right)

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