Fig. 6From: Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatmentHigh mitochondrial mass is associated with increased MTA sensitivity. The cell population with high mitochondrial mass is sensitive to pemetrexed (MTA). Mito-High: highest 10% of Mito Tracker stained cells; Mito-Low: lowest 10% of Mito Tracker stained cells. Para 3.4: unsorted Para clone cells (the subtype is 3.4) a Absolute cell numbers per well 1 week after MTA treatment at the indicated concentrations. b Normalized cell growth based on the cell numbers without MTA treatment, i.e. untreated cell numbers (a) were set as 100%. c Absolute colony numbers per well 2 weeks after MTA treatment at the indicated concentrations. d Normalized colony formation capacity based on colony numbers without MTA treatment, i.e. untreated colony numbers (c) were set as 100%. e Images of colony formation assay for the two populations Mito-High (left) and Mito-Low (right)Back to article page