Fig. 3

Schematic view of the AP-1 and PKB signaling pathways between MSCs and HCC cells in inflammation microenvironment. The pathway AP-1 transcription factor activates through various factors, including viral proteins, necrotic factors that produce ROS, IL-1α/β and TGF-β produced from MSCs, and TRAF6 is activated from the TLR inflammatory pathway. MSCs inhibit PKB pathogenic pathway so that the tumor cell goes to apoptosis