Table 1 Dual effect of MSCs on HCC
References | Effects | Cell lines | Results |
|---|---|---|---|
Hou et al. [11] | Inhibit | HEK 293 and HepG2 cell lines | Wnt signaling pathway may have a function in MSC-mediated tumor cell inhibition |
Yan-rong Lu et al. [113] | Inhibit | murine hepatoma H22, lymphoma (YAC-1 and EL-4) and rat insulinoma INS-1 cell lines | MSCs had potential inhibitory effects on tumor cell growth in vitro and in vivo without host immunosuppression, by inducing apoptotic cell death and G0/G1 phase arrest of cancer cells |
Li et al. [132] | Inhibit | MHCC97-H cell line | MSC could be useful in controlling metastatic recurrence of HCC |
Zhao et al. [133] | Inhibit | HepG2, Huh7, SMMC7721, and Bel7402 cell lines | inhibited HCC cell proliferation and division induced HCC cell death through the downregulation of Akt signaling |
El Asmar et al. [105] | Inhibit | DENA and CCl4 induction in rat model | tumor suppressive effects as evidenced by down regulation of Wnt signaling target genes concerned with anti-apoptosis, mitogenesis, cell proliferation and cell cycle regulation |
Li et al. [134] | Inhibit | MHCC97-H cell line | The metastatic potential of tumor cells was downregulated after hMSC engraftment and hMSCs induce further tumor cells apoptosis |
Qiao et al. [135] | Inhibit | H7402 and HepG2 cell lines | The Wnt signaling pathway may have a role in hMSC-mediated targeting and tumor cell inhibition |
Qiao et al. [69] | Inhibit | H7402 cell line | NF‐κB downregulation is one of reasons for the depression of tumor cell proliferation mediated by hMSCs |
Bruno et al. [136] | Inhibit | HepG2 cell line | MVs from human MSCs inhibited in vitro cell growth |
Ma et al. [137] | Inhibit | H22 cell line | BMSCs pulsed with TEX could enhance its antitumor activities |
Abd-Allah et al. [138] | Inhibit | HEPA 1-6 cell line | MSCs could inhibit cell division of HCC and potentiate their death |
Seyhoun et al. [139] | Inhibit | HepG2 cell line | Combination therapy MSCs and sorafenib to the treatment of HCC that significantly improves the results |
Hajighasemlou et al. [140] | Inhibit | HepG2 cell line | Local injection of MSCs can be used as cell therapy to fight neoplasms |
Hernanda et al. [141] | Promote | Huh7 cell line | MSCs are enriched in human HCC tumor compartment and could exert trophic effects on tumor cells |
Yan et al. [142] | Promote | MHCC97L cell line | HCC progression, and may be a potential therapeutic target |
Gong et al. [143] | Promote | HepG-2 cell line | promote the growth of microvascular in hepatoma cells |
Jing et al. [144] | Promote | SMMC-7721 cell line | MSCs in tumor inflammatory microenvironment could promote tumor metastasis through TGFβ-induced EMT |
Bhattacharya et al. [145] | Promote | SK-Hep1 cell line | stimulation of cancer-associated fibroblasts and EMT markers |
Liu et al. [146] | Promote | HCCLM3 cell line | significantly enhance the tumor cell metastasis, which was due to the EMT of HCC cells induced by TGF-β |