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Fig. 1 | Cancer Cell International

Fig. 1

From: KCNQ1OT1 aggravates cell proliferation and migration in bladder cancer through modulating miR-145-5p/PCBP2 axis

Fig. 1

KCNQ1OT1 knockdown inhibits cell proliferation, migration, invasion and EMT in BC. a, b QRT-PCR evaluated KCNQ1OT1 expression status in BC tissues, cell lines and corresponding matched groups. c The transfection efficiency of sh-KCNQ1OT1 plasmid was ensured by qRT-PCR. d, e CCK-8 and colony formation assays detected sh-KCNQ1OT1-transfected cell proliferation. f, g TUNEL and flow cytometry assays measured cell apoptosis after knockdown of KCNQ1OT1. h Wound healing assay tested sh-KCNQ1OT1-transfected cell migration ability. i Transwell assay detected cell invasion after silencing KCNQ1OT1. j Western blot measured the level of proteins associated with cell apoptosis and migration after silencing KCNQ1OT1. GAPDH was internal control. *P < 0.05, **P < 0.01

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