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Fig. 4 | Cancer Cell International

Fig. 4

From: KCNQ1OT1 aggravates cell proliferation and migration in bladder cancer through modulating miR-145-5p/PCBP2 axis

Fig. 4

Overexpression of PCBP2 rescues the tumor-inhibitor role of KCNQ1OT1 depletion in BC. a The transfection efficiency of pcDNA3.1/PCBP2 was ensured by qRT-PCR. b CCK-8 assay evaluated cell viability among sh-NC, sh-KCNQ1OT1#1 and sh-KCNQT1#1 + PCBP2 groups. c TUNEL assay examined BC cell apoptosis among sh-NC, sh-KCNQ1OT1#1 and sh-KCNQT1#1 + PCBP2 groups. d, e Wound healing and transwell assays detected cell migration and invasion respectively among sh-NC, sh-KCNQ1OT1#1 and sh-KCNQT1#1 + PCBP2 groups. f Western blot assay evaluated protein level among sh-NC, sh-KCNQ1OT1#1 and sh-KCNQT1#1 + PCBP2 groups. GAPDH was internal control. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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