High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

Table 1 Correlation of CTHRC1 and clinicopathologic characteristics in patients with LUAD

Clinicopathologic characteristics	All cases (n = 210)	CTHRC1 expression		P-value
Clinicopathologic characteristics	All cases (n = 210)	Low (n = 137)	High (n = 73)	P-value
Gender
Male	114	80	34	0.111
Female	96	57	39
Age (years)
≤ 50	64	39	25	0.432
> 50	146	98	48
Smoking
Yes	43	33	10	0.105
No	167	104	63
Tumor differentiation
Well	10	7	3	0.172
Moderately	181	114	67
Poorly	19	16	3
Clinical stage
I	130	102	28	< 0.001
II	25	11	14
III	36	18	18
IV	19	6	13
T classification
T1	76	53	23	0.025
T2	112	76	36
T3	12	5	7
T4	10	3	7
N classification
N0	146	107	39	0.001
N1	21	9	12
N2	33	18	15
N3	10	3	7
M classification
M0	195	132	63	0.011
M1	15	5	10

Fisher’s exact tests; Chi-square tests. Statistical significance (P < 0.05) is shown in italic
LUAD lung adenocarcinoma, CTHRC1 collagen triple helix repeat containing 1, TNM tumor-node-metastasis

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