Fig. 1

Interfering with HNF1A-AS1 inhibits the drug resistance and proliferation of cervical cancer cells and promotes their apoptosis. a Detection of HNF1A-AS1 expression in each cell lines by RT-qPCR. b RT-qPCR was used to detect the interference efficiency of HNF1A-AS1 in DDP-sensitive cell line HeLa/S and DDP-resistant cell line HeLa/DDP. c Detection of IC₅₀ in DDP-sensitive cell line HeLa/S and DDP-resistant cell line HeLa/DDP by MTT assay. d EdU assay was adopted to detect cell proliferation of DDP-sensitive cell line HeLa/S and DDP-resistant cell line HeLa/DDP. e Colony formation assay detected the ability of cell colony formation of DDP-sensitive cell line HeLa/S and DDP-resistant cell line HeLa/DDP. f Flow cytometry was used to detect cell apoptosis of DDP-sensitive cell line HeLa/S and DDP-resistant cell line HeLa/DDP. *P < 0.05 vs. HcerEpic cells. ^#P < 0.05 vs. the sh-NC group. Measurement data were depicted as mean ± standard deviation, comparisons between groups were conducted by non-paired t test, and comparisons among multiple groups were assessed by one-way analysis of variance, the experiment was repeated three times