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Fig. 3 | Cancer Cell International

Fig. 3

From: S-15 in combination of Akt inhibitor promotes the expansion of CD45RACCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cells

Fig. 3

Expression of PD-1 and Tim-3 on CD8+ T cells in IL-2, IL-2/S-15, IL-2/Akti and IL-2/S-15/Akti-expanded Tils. a The dynamic percentages of PD-1+Tim-3+ within CD8+T cells during the 25-day initial culture period were shown. Data represent the mean ± SEM of six independent experiments. b Representative dot plots with percentages of PD-1+Tim-3+ within CD8+T cells in different groups at day 25 are shown. c Summary data about the percentages of PD-1+Tim-3+ within CD8+T cells at day 25 which is from panel a are presented. Statistical significance was analyzed by repeated measures ANOVA

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