Fig. 5From: S-15 in combination of Akt inhibitor promotes the expansion of CD45RA−CCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cellsThe percentage of IFN-γ-producing CD8+ T cells in IL-2, IL-2/S-15, IL-2/Akti and IL-2/S-15/Akti-expanded Tils. Representative dot plots from one HCC patient (a) and summary data for HCC patients (n = 6; b) showing the percentage of IFN-γ- producing CD8+ T cells after ex vivo co-culture with autologous tumor cellsBack to article page