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Fig. 7 | Cancer Cell International

Fig. 7

From: HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1

Fig. 7

HAND2-AS1 regulates the expression of LDOC1 by binding to miR-330-5p to influence the proliferation and metastasis of cervical cancer cells. a transfection efficiency in HeLa cells tested by RT-qPCR. b LDOC1 protein expression in HeLa cells determined by Western blot analysis. c HeLa cell viability detected by CCK-8 assay. d HeLa cell invasion and migration detected by Transwell assay. e Western blot analysis of proliferation-related proteins Ki-67, PCNA, migration-related proteins N-cad, E-cad and invasion-related proteins MMP-2 and MMP-9 in HeLa cells. *p < 0.05 vs. cells treated with both oe-NC and sh-NC; #p < 0.05 vs. cells co-transfected with oe-HAND2-AS1 and sh-NC. The data of each group were measurement data, expressed as mean ± standard deviation. One-way analysis of variance was used for comparison among multiple groups followed by Tukey’s post hoc test. The experiment was repeated three times

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