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Fig. 7 | Cancer Cell International

Fig. 7

From: Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway

Fig. 7

Uev1A inhibits apoptosis through the AKT pathway in breast cancer cells. a, b UEV1A-overexpressed or vector control MDA-MB-231-TR cells with Paclitaxel (Pacl) (a) or Doxorubicin (Doxo) (b). c, d UEV1A-overexpressed or vector control MCF7 cells with Paclitaxel (Pacl) (c) or Doxorubicin (Doxo) (d). Cells were pretreated with (right panel) or without (left panel) 10 µM LY294002 (LY) for 12 h and then exposed to Paclitaxel or Doxorubicin, harvested at different time points and the protein levels of total PARP and cleaved-PARP (C-PARP) were detected by western blot. The ectopic Uev1A was monitored by an anti-HA antibody

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