Fig. 8
From: Uev1A promotes breast cancer cell survival and chemoresistance through the AKT-FOXO1-BIM pathway
Uev1A promotes cell survival through the AKT-FOXO1-BIM axis in breast cancer cells. The Ubc13-Uev1A complex works as an E2 along with TRAF6 to ubiquitinate AKT, which is required for the AKT membrane recruitment and subsequent phosphorylation and activation. The AKT phosphorylation negatively regulates the transcription factor FOXO1 that induces the expression of a pro-apoptosis gene BIM to trigger apoptosis