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Fig. 5 | Cancer Cell International

Fig. 5

From: Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A

Fig. 5

CAF-derived exosomal miR-98-5p stimulates cisplatin resistance in OC cells by targeting CDKN1A. A2780 cells transfected with oe-CDKN1A or oe-NC were co-cultured with CAF-exo and further treated with cisplatin. a Cell proliferation as detected by CCK-8 assay. b OC cell colony formation ability as detected by colony formation assay. c Statistical analysis for b. d OC cell cycle distribution as detected by flow cytometry. e Statistical analysis for d. f OC cell apoptosis as detected by flow cytometry. g Statistical analysis for f. *p < 0.05 vs. NC-exo + oe-NC; #p < 0.05 vs. NC-exo + oe-CDKN1A; &cells without treatment of cisplatin. These data were measurement data, expressed as mean ± standard deviation. Data between two groups were compared using unpaired t-test. Data among multiple groups were compared using one-way analysis of variance and further analyzed with Tukey’s post hoc test. Comparisons among multiple groups at different time points were analyzed using repeated measures ANOVA, followed by Bonferroni post hoc test. The experiment was repeated three times

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