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Fig. 6 | Cancer Cell International

Fig. 6

From: Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A

Fig. 6

Exosomal miR-98-5p downregulates CDKN1A and promotes cisplatin resistance in transplanted tumors in nude mice. Nude mice were injected with agomir-NC-exo and agomir-miR-98-5p-exo. a The volume curve of transplanted tumors in nude mice. b observation of tumors from nude mice. c The weight of transplanted tumors in nude mice. d miR-98-5p and CDKN1A expression in tumor tissues as detected by RT-qPCR. e CDKN1A expression as detected by Western blot analysis. f Statistical analysis for e. *p < 0.05 vs. control mice; #p < 0.05 vs. the injection of agomir-NC-exo. These data were measurement data, expressed as mean ± standard deviation. Data between two groups were compared using unpaired t-test. Data among multiple groups were compared using one-way analysis of variance and further analyzed with Tukey’s post hoc test. Comparisons among multiple groups at different time points were analyzed using repeated measures ANOVA, followed by Bonferroni post hoc test. The experiment was repeated three times

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