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Table 1 Top 15 significantly enriched pathways derived from the DEmRNAs

From: Identification and analysis of long non-coding RNA related miRNA sponge regulatory network in bladder urothelial carcinoma

IDDescriptionP valueP adjustq valueGene IDCount
hsa05322Systemic lupus erythematosus5.1E−201.47E−171.23E−17ELANE/C7/HIST3H2A/CTSG/HIST1H2AD/HIST1H3D/HIST1H2BD/
HIST2H2BF/HIST1H3G/HIST1H2AE/HIST1H2BJ/HIST3H2BB/
HIST1H2BO/HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2AG/
HIST1H2BE/HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/
HIST1H3B/HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/
HIST1H2AH/HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/
HIST1H2BN/HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/
HIST1H4B/HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/
HIST1H2AB/HIST1H3A/HIST1H4A/HIST1H4H/FCGR3A/
HIST1H2BB/HIST1H2AJ/H2BFM/HIST1H4F/HIST1H4L
52
hsa05034Alcoholism3.48E−185.02E−164.2E−16FOSB/GNAO1/GNG7/ADCY5/MAOB/HIST3H2A/HIST1H2AD/
HIST1H3D/HIST1H2BD/HIST2H2BF/HIST1H3G/HIST1H2AE/
HIST1H2BJ/GRIN2D/HIST3H2BB/HIST1H2BO/HIST1H4I/
HIST1H2BG/HIST1H2BH/GRIN3B/HIST1H2AG/HIST1H2BE/
HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/HIST1H3B/
HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/HIST1H2AH/
HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/HIST1H2BN/
HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/HIST1H4B/
HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/HIST1H2AB/
GRIN1/HIST1H3A/HIST1H4A/HIST1H4H/HIST1H2BB/
HIST1H2AJ/GNG4/GNG13/H2BFM/HIST1H4F/TH/HIST1H4L
59
hsa04080Neuroactive ligand–receptor interaction9.5E−109.12E−087.63E−08GLP2R/TACR2/P2RX1/P2RY14/VIPR2/TACR3/PTGFR/CHRM2/
ADRB3/AGTR1/CHRM3/LEPR/ADCYAP1R1/PTH1R/BDKRB1/
BDKRB2/ADRA1D/GHR/HTR1B/CTSG/TACR1/GRIN2D/
CHRNA1/GRIN3B/PTGER3/GRIK3/HTR2A/GABRG1/SSTR1/
S1PR5/GALR1/LHB/PRSS2/PRSS1/GRIN1/GRM4/MTNR1B/
GABRA4/KISS1R/OXTR/CHRNG/CHRNB2/PRLHR/CHRND/
CHRNA9/GRM3/GALR2/CHRNA6/GPR83/GLP1R/GLRA3/
SCTR/F2/DRD5/GABRR3/HTR2C/RXFP3/GHRHR/GABBR2/PRL
60
hsa05410Hypertrophic cardiomyopathy (HCM)1.34E−099.68E−088.1E−08TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/ITGA7/
SGCA/RYR2/SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/
ITGA1/TNNT2/IL6/CACNB4/PRKAA2/CACNA2D1/ITGB3/
MYL3/TNNI3/CACNG4/CACNG1
28
hsa05414Dilated cardiomyopathy (DCM)2.31E−091.33E−071.11E−07TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/PLN/
ITGA7/SGCA/RYR2/SLC8A1/LAMA2/DES/ADCY5/SGCD/
SGCG/ITGA5/ITGA9/ITGA1/TNNT2/CACNB4/CACNA2D1/
ITGB3/MYL3/ADCY2/TNNI3/CACNG4/CACNG1
29
hsa04020Calcium signaling pathway6.17E−082.96E−062.48E−06PLCD4/MYLK/TACR2/ITPKB/RYR3/CACNA1H/PDE1C/P2RX1/
ITPR1/GNAL/CACNA1C/PLN/PDE1A/CAMK2A/TACR3/RYR2/
PTGFR/SLC8A1/PLCB4/CHRM2/ADRB3/AGTR1/CHRM3/
BDKRB1/BDKRB2/ADRA1D/PRKCB/TACR1/SLC8A3/GRIN2D/
ADCY2/PTGER3/SLC8A2/HTR2A/GRIN1/OXTR/CAMK2B/
CACNA1E/MYLK4/DRD5/CACNA1B/HTR2C
42
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)5.72E−072.35E−051.97E−05DMD/ITGA8/ACTN2/CACNB2/CACNA1C/ITGA7/SGCA/RYR2/
SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/ITGA1/
CACNB4/CACNA2D1/ITGB3/CTNNA3/CACNG4/CACNG1
22
hsa04713Circadian entrainment2.72E−068.74E−057.32E−05RYR3/CACNA1H/PER2/ITPR1/FOS/CACNA1C/GNAO1/CAMK2A/
GNG7/PRKG1/RYR2/PLCB4/ADCY5/PER1/ADCYAP1R1/PRKCB/
KCNJ3/GRIN2D/ADCY2/GRIN1/MTNR1B/CAMK2B/KCNJ6/
GNG4/GNG13
25
hsa04974Protein digestion and absorption2.73E−068.74E−057.32E−05ATP1A2/SLC8A1/COL14A1/ATP1B2/XPNPEP2/COL10A1/CPA3/
COL21A1/SLC8A3/COL11A1/ELN/COL4A4/COL4A6/SLC8A2/
COL7A1/COL2A1/COL6A5/PRSS2/SLC15A1/PRSS1/MEP1A/
ATP1A3/CPB2/SLC6A19
24
hsa04911Insulin secretion3.35E−069.66E−058.09E−05KCNMA1/KCNMB1/ATP1A2/CACNA1C/CAMK2A/RYR2/PLCB4/
ADCY5/ATP1B2/CHRM3/ADCYAP1R1/ADCYAP1/KCNN2/
PRKCB/ADCY2/ABCC8/PDX1/CAMK2B/ATP1A3/GLP1R/INS/
SLC2A2/GIP
23
hsa05203Viral carcinogenesis6.19E−060.0001620.000136EGR3/GSN/JUN/CDK1/EGR2/CDC20/CCNE1/HIST1H2BD/
HIST2H2BF/HIST1H2BJ/CCNE2/HIST3H2BB/HIST1H2BO/
HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2BE/HIST1H2BF/
HIST1H2BC/HIST1H2BK/HIST1H4E/GTF2A1L/HIST2H4A/
CCR3/CDKN2A/HIST1H2BM/HIST1H4D/HIST1H2BN/
HIST1H2BI/HIST1H4C/ATP6V0D2/HIST1H4B/HIST1H2BL/
HIST1H4A/HIST1H4H/HIST1H2BB/H2BFM/HIST1H4F/
HPN/HIST1H4L
40
hsa04512ECM–receptor interaction2.24E−050.0005380.00045TNXB/ITGA8/ITGA7/THBS1/LAMA2/ITGA5/ITGA9/ITGA1/
LAMC3/ITGB3/HMMR/COL4A4/COL4A6/SPP1/IBSP/
COL2A1/COL6A5/LAMC2/GP6/COMP/TNN
21
hsa04921Oxytocin signaling pathway0.0001040.002310.001933PPP1R12B/MYLK/RYR3/MYL9/ITPR1/RCAN1/FOS/
CACNB2/CACNA1C/GNAO1/CAMK2A/RGS2/RYR2/
PLCB4/JUN/ADCY5/CACNB4/PRKAA2/CACNA2D1/
PRKCB/PTGS2/KCNJ3/ADCY2/OXTR/CACNG4/
CAMK2B/KCNJ6/MYLK4/KCNJ4/CACNG1
30
hsa04024cAMP signaling pathway0.0001310.0026960.002257MYL9/FOS/ATP1A2/PDE4D/CACNA1C/PLN/
CAMK2A/FXYD1/VIPR2/CNGA3/RYR2/JUN/CHRM2/
ADCY5/ATP1B2/ADCYAP1R1/RAC3/HTR1B/HHIP/
GRIN2D/ADCY2/GRIN3B/TNNI3/PTGER3/CNGB1/
SSTR1/CNGB3/AMH/GRIN1/OXTR/CAMK2B/
SUCNR1/ATP1A3/GLP1R/DRD5/GABBR2
36
hsa04261Adrenergic signaling in cardiomyocytes0.0002290.0043930.003677TPM1/CACNB2/ACTC1/ATP1A2/CACNA1C/TPM2/
PLN/CAMK2A/RYR2/SLC8A1/PLCB4/ADCY5/
ATP1B2/TNNT2/AGTR1/SCN7A/CACNB4/SCN4B/
PPP1R1A/ADRA1D/CACNA2D1/MYL3/ADCY2/
TNNI3/CACNG4/CAMK2B/ATP1A3/CACNG1
28