Table 1 Top 15 significantly enriched pathways derived from the DEmRNAs

hsa05322

Systemic lupus erythematosus

5.1E−20

1.47E−17

1.23E−17

ELANE/C7/HIST3H2A/CTSG/HIST1H2AD/HIST1H3D/HIST1H2BD/

HIST2H2BF/HIST1H3G/HIST1H2AE/HIST1H2BJ/HIST3H2BB/

HIST1H2BO/HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2AG/

HIST1H2BE/HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/

HIST1H3B/HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/

HIST1H2AH/HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/

HIST1H2BN/HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/

HIST1H4B/HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/

HIST1H2AB/HIST1H3A/HIST1H4A/HIST1H4H/FCGR3A/

HIST1H2BB/HIST1H2AJ/H2BFM/HIST1H4F/HIST1H4L

hsa05034

Alcoholism

3.48E−18

5.02E−16

4.2E−16

FOSB/GNAO1/GNG7/ADCY5/MAOB/HIST3H2A/HIST1H2AD/

HIST1H3D/HIST1H2BD/HIST2H2BF/HIST1H3G/HIST1H2AE/

HIST1H2BJ/GRIN2D/HIST3H2BB/HIST1H2BO/HIST1H4I/

HIST1H2BG/HIST1H2BH/GRIN3B/HIST1H2AG/HIST1H2BE/

HIST1H2BF/HIST1H2BC/HIST1H2BK/HIST1H2AI/HIST1H3B/

HIST1H3H/HIST1H4E/HIST2H4A/HIST1H2AM/HIST1H2AH/

HIST1H3C/HIST1H2BM/HIST1H4D/HIST1H2AL/HIST1H2BN/

HIST1H2BI/HIST1H3F/HIST2H3D/HIST1H4C/HIST1H4B/

HIST1H3I/HIST2H2AB/HIST1H3J/HIST1H2BL/HIST1H2AB/

GRIN1/HIST1H3A/HIST1H4A/HIST1H4H/HIST1H2BB/

HIST1H2AJ/GNG4/GNG13/H2BFM/HIST1H4F/TH/HIST1H4L

hsa04080

Neuroactive ligand–receptor interaction

9.5E−10

9.12E−08

7.63E−08

GLP2R/TACR2/P2RX1/P2RY14/VIPR2/TACR3/PTGFR/CHRM2/

ADRB3/AGTR1/CHRM3/LEPR/ADCYAP1R1/PTH1R/BDKRB1/

BDKRB2/ADRA1D/GHR/HTR1B/CTSG/TACR1/GRIN2D/

CHRNA1/GRIN3B/PTGER3/GRIK3/HTR2A/GABRG1/SSTR1/

S1PR5/GALR1/LHB/PRSS2/PRSS1/GRIN1/GRM4/MTNR1B/

GABRA4/KISS1R/OXTR/CHRNG/CHRNB2/PRLHR/CHRND/

CHRNA9/GRM3/GALR2/CHRNA6/GPR83/GLP1R/GLRA3/

SCTR/F2/DRD5/GABRR3/HTR2C/RXFP3/GHRHR/GABBR2/PRL

hsa05410

Hypertrophic cardiomyopathy (HCM)

1.34E−09

9.68E−08

8.1E−08

TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/ITGA7/

SGCA/RYR2/SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/

ITGA1/TNNT2/IL6/CACNB4/PRKAA2/CACNA2D1/ITGB3/

MYL3/TNNI3/CACNG4/CACNG1

hsa05414

Dilated cardiomyopathy (DCM)

2.31E−09

1.33E−07

1.11E−07

TPM1/DMD/ITGA8/CACNB2/ACTC1/CACNA1C/TPM2/PLN/

ITGA7/SGCA/RYR2/SLC8A1/LAMA2/DES/ADCY5/SGCD/

SGCG/ITGA5/ITGA9/ITGA1/TNNT2/CACNB4/CACNA2D1/

ITGB3/MYL3/ADCY2/TNNI3/CACNG4/CACNG1

hsa04020

Calcium signaling pathway

6.17E−08

2.96E−06

2.48E−06

PLCD4/MYLK/TACR2/ITPKB/RYR3/CACNA1H/PDE1C/P2RX1/

ITPR1/GNAL/CACNA1C/PLN/PDE1A/CAMK2A/TACR3/RYR2/

PTGFR/SLC8A1/PLCB4/CHRM2/ADRB3/AGTR1/CHRM3/

BDKRB1/BDKRB2/ADRA1D/PRKCB/TACR1/SLC8A3/GRIN2D/

ADCY2/PTGER3/SLC8A2/HTR2A/GRIN1/OXTR/CAMK2B/

CACNA1E/MYLK4/DRD5/CACNA1B/HTR2C

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

5.72E−07

2.35E−05

1.97E−05

DMD/ITGA8/ACTN2/CACNB2/CACNA1C/ITGA7/SGCA/RYR2/

SLC8A1/LAMA2/DES/SGCD/SGCG/ITGA5/ITGA9/ITGA1/

CACNB4/CACNA2D1/ITGB3/CTNNA3/CACNG4/CACNG1

hsa04713

Circadian entrainment

2.72E−06

8.74E−05

7.32E−05

RYR3/CACNA1H/PER2/ITPR1/FOS/CACNA1C/GNAO1/CAMK2A/

GNG7/PRKG1/RYR2/PLCB4/ADCY5/PER1/ADCYAP1R1/PRKCB/

KCNJ3/GRIN2D/ADCY2/GRIN1/MTNR1B/CAMK2B/KCNJ6/

GNG4/GNG13

hsa04974

Protein digestion and absorption

2.73E−06

8.74E−05

7.32E−05

ATP1A2/SLC8A1/COL14A1/ATP1B2/XPNPEP2/COL10A1/CPA3/

COL21A1/SLC8A3/COL11A1/ELN/COL4A4/COL4A6/SLC8A2/

COL7A1/COL2A1/COL6A5/PRSS2/SLC15A1/PRSS1/MEP1A/

ATP1A3/CPB2/SLC6A19

hsa04911

Insulin secretion

3.35E−06

9.66E−05

8.09E−05

KCNMA1/KCNMB1/ATP1A2/CACNA1C/CAMK2A/RYR2/PLCB4/

ADCY5/ATP1B2/CHRM3/ADCYAP1R1/ADCYAP1/KCNN2/

PRKCB/ADCY2/ABCC8/PDX1/CAMK2B/ATP1A3/GLP1R/INS/

SLC2A2/GIP

hsa05203

Viral carcinogenesis

6.19E−06

0.000162

0.000136

EGR3/GSN/JUN/CDK1/EGR2/CDC20/CCNE1/HIST1H2BD/

HIST2H2BF/HIST1H2BJ/CCNE2/HIST3H2BB/HIST1H2BO/

HIST1H4I/HIST1H2BG/HIST1H2BH/HIST1H2BE/HIST1H2BF/

HIST1H2BC/HIST1H2BK/HIST1H4E/GTF2A1L/HIST2H4A/

CCR3/CDKN2A/HIST1H2BM/HIST1H4D/HIST1H2BN/

HIST1H2BI/HIST1H4C/ATP6V0D2/HIST1H4B/HIST1H2BL/

HIST1H4A/HIST1H4H/HIST1H2BB/H2BFM/HIST1H4F/

HPN/HIST1H4L

hsa04512

ECM–receptor interaction

2.24E−05

0.000538

0.00045

TNXB/ITGA8/ITGA7/THBS1/LAMA2/ITGA5/ITGA9/ITGA1/

LAMC3/ITGB3/HMMR/COL4A4/COL4A6/SPP1/IBSP/

COL2A1/COL6A5/LAMC2/GP6/COMP/TNN

hsa04921

Oxytocin signaling pathway

0.000104

0.00231

0.001933

PPP1R12B/MYLK/RYR3/MYL9/ITPR1/RCAN1/FOS/

CACNB2/CACNA1C/GNAO1/CAMK2A/RGS2/RYR2/

PLCB4/JUN/ADCY5/CACNB4/PRKAA2/CACNA2D1/

PRKCB/PTGS2/KCNJ3/ADCY2/OXTR/CACNG4/

CAMK2B/KCNJ6/MYLK4/KCNJ4/CACNG1

hsa04024

cAMP signaling pathway

0.000131

0.002696

0.002257

MYL9/FOS/ATP1A2/PDE4D/CACNA1C/PLN/

CAMK2A/FXYD1/VIPR2/CNGA3/RYR2/JUN/CHRM2/

ADCY5/ATP1B2/ADCYAP1R1/RAC3/HTR1B/HHIP/

GRIN2D/ADCY2/GRIN3B/TNNI3/PTGER3/CNGB1/

SSTR1/CNGB3/AMH/GRIN1/OXTR/CAMK2B/

SUCNR1/ATP1A3/GLP1R/DRD5/GABBR2

hsa04261

Adrenergic signaling in cardiomyocytes

0.000229

0.004393

0.003677

TPM1/CACNB2/ACTC1/ATP1A2/CACNA1C/TPM2/

PLN/CAMK2A/RYR2/SLC8A1/PLCB4/ADCY5/

ATP1B2/TNNT2/AGTR1/SCN7A/CACNB4/SCN4B/

PPP1R1A/ADRA1D/CACNA2D1/MYL3/ADCY2/

TNNI3/CACNG4/CAMK2B/ATP1A3/CACNG1