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Fig. 6 | Cancer Cell International

Fig. 6

From: miR-100-3p inhibits cell proliferation and induces apoptosis in human gastric cancer through targeting to BMPR2

Fig. 6

Knockdown of BMPR2 expression neutralized the effect of the miR-100-3p inhibitor; also over-expression of BMPR2 neutralized the effect of the miR-100-3p over-expression. BMPR2 reversed the effect induced by miR-100-3p dysregulation. a, b Proliferation of AGS cells transfected with Lv-miR-100-3p mimic-control (Lv-miR-100-3p mimic-ctrl) and over-expression BMPR2 plasmid control (over-expression BMPR2 control-ctrl), Lv-miR-100-3p mimic-ctrl and over-expression BMPR2 plasmid, Lv-miR-100-3p mimic and over-expression BMPR2-ctrl, or Lv-miR-100-3p mimic and over-expression BMPR2 plasmid. MGC-803 cells transfected with Lv-miR-100-3p inhibitor-control (inhibitor-ctrl) and BMPR2 shRNA control (shRNA-ctrl), Lv-miR-100-3p inhibitor-ctrl and BMPR2 shRNA, Lv-miR-100-3p inhibitor and BMPR2 shRNA-ctrl, or Lv-miR-100-3p inhibitor and BMPR2 shRNA was examined by MTT assay c, d Flow analysis revealed the apoptosis of AGS and MGC-803 cells with or without DDP supplementation (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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