Fig. 4

Sulforaphene induce tumor apoptosis through MSK2–CREB–Bcl-2 pathway. a Immunoblot analysis of the indicated MSK2, CREB and Bcl-2 expression levels in Eca109 cells with quantification data (n = 3). b IHC assays showed the expression levels of Bcl-2, and p-cadherin in both control and sulforaphene-treated tumor tissues isolated from mice. Data are expressed as the mean ± SD. * Indicates P < 0.05. c Comparisons of tumor volumes in representative mice in the control, low, and high sulforaphene-treated groups