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Fig. 6 | Cancer Cell International

Fig. 6

From: Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway

Fig. 6

Circ-SOX4 promotes LUAD progression through miR-1270/PLAGL2/WNT/β-catenin signaling pathway. a TOP/FOP flash assay evaluated the influences of different concentration of pcDNA3.1/PLAGL2 on the luciferase activity of TOP and FOP reporters. b The luciferase activities of TOP and FOP reporters in sh-NC and sh-circ-SOX4 groups were assessed by TOP/FOP flash assay. c, d qRT-PCR and western blot assay, respectively evaluated the level of WNT pathway-related mRNAs and proteins in SPC-A1/sh-circ-SOX4 cells. *P < 0.05, **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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