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Fig. 4 | Cancer Cell International

Fig. 4

From: TGF-β1 stimulates epithelial–mesenchymal transition and cancer-associated myoepithelial cell during the progression from in situ to invasive breast cancer

Fig. 4

Myoepithelial cell marker expressions in adjacent normal breast tissue, DCIS and IDC. a1 SMA staining was continuously present in the myoepithelial cells layer and cytoplasm of the ductal-lobular system of adjacent normal breast tissue, and in the myoepithelial cell layer of DCIS (b1); Loss of SMA is evident in IDC (c1). a2 p63 stains were continuously expressed in the myoepithelial cell layer and nucleus of the ductal-lobular system of healthy breast tissue and was either discontinuously or absently expressed in the myoepithelial cell layer of DCIS (b2). Loss of p63 is evident in IDC (c2). a3 Calponin staining was continuously present in the myoepithelial cells layer and nucleus of the ductal-lobular system of healthy breast tissue, and in the myoepithelial cell layer of DCIS (b3); Loss of Calponin is evident in IDC (c3). Original magnification× 200. d Expression of myoepithelial cell markers in adjacent normal breast tissue, DCIS and IDC cases ***p < 0.001

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