Table 4 Univariable and multivariable Cox analysis of the risk score and clinical information in entire series

Risk score

 Low

1 (Reference)

1 (Reference)

 High

3.684 (2.359–5.753)

< 0.0001

2.981 (1.575–5.642)

0.001

Gender

 Female

1 (Reference)

 Male

1.132 (0.764–1.677)

0.536

Age

 < 68

1 (Reference)

1 (Reference)

 ≥ 68

1.821 (1.197–2.771)

0.005

2.040 (1.132–3.677)

0.018

TNM

 I + II

1 (Reference)

1 (Reference)

 III + IV

2.953 (1.935–4.507)

< 0.0001

2.081 (0.949–4.560)

0.067

T stage

 T0 + 1

1 (Reference)

1 (Reference)

 T2 + 3

2.759 (1.275–5.973)

0.010

3.180 (0.737–13.726)

0.121

N stage

 N0 + 1

1 (Reference)

1 (Reference)

 N2

3.575 (2.378–5.373)

< 0.0001

1.299(0.678–2.489)

0.431

M stage

 M0

1 (Reference)

1 (Reference)

 M1

4.294(2.736–6.738)

< 0.0001

1.702(0.862–3.359)

0.126

Cancer status

 No

1 (Reference)

1 (Reference)

 Yes

3.330 (2.009–5.521)

< 0.0001

3.126 (1.491–6.552)

0.003

Race

 Non-white

1 (Reference)

 White

0.884 (0.496–1.576)

0.676

Lymphatic invasion

 No

1 (Reference)

1 (Reference)

 Yes

2.314(1.517–3.530)

< 0.0001

0.877 (0.463–1.663)

0.688

Microsatallite instability

 No

1 (Reference)

 Yes

26.379 (0.127–5479.857)

0.229

History colon polyps

 No

1 (Reference)

 Yes

0.758 (0.447–1.284)

0.302