Fig. 1

LncRNA-CIR is up-regulated in osteosarcoma tissues and cells, and the highly-expressed lncRNA-CIR indicates a poor prognosis of osteosarcoma patients. a LncRNA-CIR expression in osteosarcoma tissues and adjacent normal tissues; b LncRNA-CIR expression in hFOB1.19, MG63, 143B, U2OS and SAOS2 cells; c Relation between lncRNA-CIR expression and prognosis of osteosarcoma patients; d LncRNA-CIR expression in MG63 cells of each group; e LncRNA-CIR expression in 143B cells of each group; the normal group and the tumor group: n = 54, hFOB1.19, MG63, 143B, U2OS and SAOS2: N = 3; lncRNA-CIR high expression: n = 36, low expression: n = 18; differences among the curves were analyzed by Log-rank test; ^#P < 0.05 vs hFOB1.19 cells, *P < 0.05 vs the sh-NC group, ⁺P < 0.05 vs the oe-NC group. The measurement data conforming to the normal distribution were expressed as mean ± standard deviation, one-way ANOVA was used for comparisons among multiple groups and Tukey’s post hoc test was used for pairwise comparisons after one-way ANOVA