Fig. 9

Inhibited lncRNA-CIR reduces proliferation while accelerates apoptosis of osteosarcoma cells in xenografts. a/c Ki-67 expression in xenografts from nude mice that had been subcutaneously injected with MG63 and 143B cells (50 μm), and the comparisons of proliferation index among the groups; b/d Representative images of TUNEL staining in xenografts from nude mice that had been subcutaneously injected with MG63 and 143B cells (50 μm), and the comparisons of apoptotic index among the groups; n = 5, *P < 0.05 vs the sh-NC group, ⁺P < 0.05 vs the oe-NC group. The measurement data conforming to the normal distribution were expressed as mean ± standard deviation, one-way ANOVA was used for comparisons among multiple groups and Tukey’s post hoc test was used for pairwise comparisons after one-way ANOVA