Fig. 5
From: RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer
RAD51 regulates aerobic glycolysis in pancreatic cancer cells. a, b RAD51 knockdown inhibited aerobic glycolysis as demonstrated by ECAR measurements. c, d RAD51 knockdown increased OCR values in PANC-1 and MiaPaCa-2 cells, further demonstrating the negative role of RAD51 in mitochondrial respiration. e, f RAD51 knockdown decreased lactate production in PANC-1 and MiaPaCa-2 cells. g, h Silencing of RAD51 expression inhibited the expression of key glycolytic genes, including GLUT1, HK2 and LDHA, in PANC-1 and MiaPaCa-2 cells