Table 2 Correlation of clinico-pathological features with UBQLN4 expression in ZZU HCC cohort
From: UBQLN4 promotes progression of HCC via activating wnt-β-catenin pathway and is regulated by miR-370
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | |
Age (> 50 vs. ≤ 50) | 1.143 | 0.884–1.413 | 0.863 | |||
Gender (female vs. ≤ male) | 0.846 | 0.534–1.342 | 0.479 | |||
Pathogenesis (virus vs. ≤ others) | 0.784 | 0.341–1.341 | 0.243 | |||
AFP (> 20 vs. ≤ 20) | 1.270 | 0.684–1.654 | 0.347 | |||
Child-Pugh (C vs. A and B) | 1.814 | 1.491–2.765 | 0.029 | 1.674 | 0.988–1.910 | 0.190 |
Cirrhosis (present vs. absent) | 1.515 | 0.812–2.825 | 0.192 | |||
Vascular invasion (present vs. absent) | 1.848 | 1.225–2.793 | 0.003 | 2.180 | 1.416–2.404 | 0.022 |
TNM stage (III and IV vs. I and II) | 3.333 | 2.262–4.902 | 0.000 | 3.907 | 2.613–5.461 | 0.026 |
Tumor size (> 5 vs. ≤ 5) | 1.751 | 1.198–2.564 | 0.004 | 1.384 | 1.020–1.678 | 0.296 |
Tumor multiplicity (multiple vs. single) | 2.964 | 2.176–3.472 | 0.019 | 1.977 | 1.323–2.401 | 0.054 |
UBQLN4 expression (high vs. low) | 3.049 | 2.215–4.651 | 0.024 | 2.799 | 1.963–4.338 | 0.006 |