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Table 3 Univariable and multivariable Cox regression model analyses of overall survival in nomogram cohort

From: Prognostic nomograms for predicting cause-specific survival and overall survival of stage I–III colon cancer patients: a large population-based study

Variable

Univariable analysis

Multivariable analysis

HR

95% CI

P-value

HR

95% CI

P-value

Gender

  

0.017

  

0.001

 Female

1

  

1

  

 Male

1.005

1.002–1.036

 

1.248

1.190–1.309

 

Race

  

0.097

   

 White

1

     

 Othera

0.970

0.935–1.006

    

Year of diagnosis

  

0.082

   

 2010–2012

1

     

 2013–2015

0.957

0.910–1.006

    

Age at diagnosis

  

< 0.001

  

< 0.001

 < 60

1

  

1

  

 ≥ 60

2.724

2.560–2.899

 

2.228

2.086–2.379

 

Tumor site

  

< 0.001

  

< 0.001

 Right

1

  

1

  

 Left

0.753

0.719–0.789

 

0.865

0.825–0.908

 

Histological subtype

  

< 0.001

  

0.001

 AD

1

  

1

  

 MAD

1.260

1.170–1.358

< 0.001

1.024

0.949–1.104

0.540

 SRCC

2.947

2.500–3.474

< 0.001

1.403

1.184–1.663

< 0.001

Pathologic grade

  

< 0.001

  

< 0.001

 Grade I

1

  

1

  

 Grade II

1.199

1.090–1.320

< 0.001

1.029

0.934–1.134

0.557

 Grade III

1.923

1.734–2.134

< 0.001

1.206

1.083–1.342

0.001

 Grade IV

2.371

2.064–2.724

< 0.001

1.418

1.231–1.634

< 0.001

T stage

  

< 0.001

  

< 0.001

 T1

1

  

1

  

 T2

1.462

1.292–1.654

< 0.001

1.317

1.162–1.493

< 0.001

 T3

2.268

2.034–2.528

< 0.001

1.769

1.576–1.987

< 0.001

 T4a

4.671

4.146–5.262

< 0.001

3.114

2.737–3.543

< 0.001

 T4b

5.110

4.498–5.806

< 0.001

3.634

3.163–4.175

< 0.001

N stage

  

< 0.001

  

< 0.001

 N0

1

  

1

  

 N1

1.533

1.456–1.615

< 0.001

1.646

1.444–1.876

< 0.001

 N2

2.557

2.413–2.709

< 0.001

2.364

2.035–2.746

< 0.001

Chemotherapy

  

< 0.001

  

< 0.001

 No

1

  

1

  

 Yes

0.733

0.697–0.771

 

0.429

0.404–0.455

 

LNH

  

< 0.001

  

< 0.001

 < 12

1

  

1

  

 ≥ 12

0.674

0.633–0.717

 

0.621

0.581–0.663

 

LODDS stage

  

< 0.001

  

< 0.001

 LODDS 1

1

  

1

  

 LODDS 2

1.674

1.598–1.754

< 0.001

1.247

1.093–1.423

0.001

 LODDS 3

3.941

3.602–4.312

< 0.001

1.853

1.570–2.188

< 0.001

 LODDS 4

10.562

8.166–13.662

< 0.001

3.592

2.674–4.825

< 0.001

Tumor size

  

< 0.001

  

0.048

 < 4

1

  

1

  

 ≥ 4

1.446

1.379–1.517

 

1.050

1.004–1.102

 

CEA

  

< 0.001

  

< 0.001

 Negative

1

  

1

  

 Positive

1.943

1.858–2.032

 

1.515

1.446–1.587

 

Marriage status

  

< 0.001

  

< 0.001

 Married

1

  

1

  

 Single

1.318

1.220–1.423

< 0.001

1.266

1.171–1.367

< 0.001

 Separated/divorced

1.366

1.279–1.460

< 0.001

1.394

1.304–1.491

< 0.001

 Widowed

2.375

2.248–2.510

< 0.001

1.756

1.654–1.865

< 0.001

  1. HR hazard ratio, CI confidence interval, AD adenocarcinoma, MAD mucinous adenocarcinoma, SRCC signet ring cell carcinoma, LNH lymph nodes harvested, LODDS log of odds between the number of positive lymph node and the number of negative lymph node, CEA carcinoembryonic antigen, TNM tumor-node-metastasis
  2. aIncludes Native American, Asian, Pacific Islander and Unknown