Variable | Univariable analysis | Multivariable analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | |
Gender | 0.017 | 0.001 | ||||
Female | 1 | 1 | ||||
Male | 1.005 | 1.002–1.036 | 1.248 | 1.190–1.309 | ||
Race | 0.097 | |||||
White | 1 | |||||
Othera | 0.970 | 0.935–1.006 | ||||
Year of diagnosis | 0.082 | |||||
2010–2012 | 1 | |||||
2013–2015 | 0.957 | 0.910–1.006 | ||||
Age at diagnosis | < 0.001 | < 0.001 | ||||
< 60 | 1 | 1 | ||||
≥ 60 | 2.724 | 2.560–2.899 | 2.228 | 2.086–2.379 | ||
Tumor site | < 0.001 | < 0.001 | ||||
Right | 1 | 1 | ||||
Left | 0.753 | 0.719–0.789 | 0.865 | 0.825–0.908 | ||
Histological subtype | < 0.001 | 0.001 | ||||
AD | 1 | 1 | ||||
MAD | 1.260 | 1.170–1.358 | < 0.001 | 1.024 | 0.949–1.104 | 0.540 |
SRCC | 2.947 | 2.500–3.474 | < 0.001 | 1.403 | 1.184–1.663 | < 0.001 |
Pathologic grade | < 0.001 | < 0.001 | ||||
Grade I | 1 | 1 | ||||
Grade II | 1.199 | 1.090–1.320 | < 0.001 | 1.029 | 0.934–1.134 | 0.557 |
Grade III | 1.923 | 1.734–2.134 | < 0.001 | 1.206 | 1.083–1.342 | 0.001 |
Grade IV | 2.371 | 2.064–2.724 | < 0.001 | 1.418 | 1.231–1.634 | < 0.001 |
T stage | < 0.001 | < 0.001 | ||||
T1 | 1 | 1 | ||||
T2 | 1.462 | 1.292–1.654 | < 0.001 | 1.317 | 1.162–1.493 | < 0.001 |
T3 | 2.268 | 2.034–2.528 | < 0.001 | 1.769 | 1.576–1.987 | < 0.001 |
T4a | 4.671 | 4.146–5.262 | < 0.001 | 3.114 | 2.737–3.543 | < 0.001 |
T4b | 5.110 | 4.498–5.806 | < 0.001 | 3.634 | 3.163–4.175 | < 0.001 |
N stage | < 0.001 | < 0.001 | ||||
N0 | 1 | 1 | ||||
N1 | 1.533 | 1.456–1.615 | < 0.001 | 1.646 | 1.444–1.876 | < 0.001 |
N2 | 2.557 | 2.413–2.709 | < 0.001 | 2.364 | 2.035–2.746 | < 0.001 |
Chemotherapy | < 0.001 | < 0.001 | ||||
No | 1 | 1 | ||||
Yes | 0.733 | 0.697–0.771 | 0.429 | 0.404–0.455 | ||
LNH | < 0.001 | < 0.001 | ||||
< 12 | 1 | 1 | ||||
≥ 12 | 0.674 | 0.633–0.717 | 0.621 | 0.581–0.663 | ||
LODDS stage | < 0.001 | < 0.001 | ||||
LODDS 1 | 1 | 1 | ||||
LODDS 2 | 1.674 | 1.598–1.754 | < 0.001 | 1.247 | 1.093–1.423 | 0.001 |
LODDS 3 | 3.941 | 3.602–4.312 | < 0.001 | 1.853 | 1.570–2.188 | < 0.001 |
LODDS 4 | 10.562 | 8.166–13.662 | < 0.001 | 3.592 | 2.674–4.825 | < 0.001 |
Tumor size | < 0.001 | 0.048 | ||||
< 4 | 1 | 1 | ||||
≥ 4 | 1.446 | 1.379–1.517 | 1.050 | 1.004–1.102 | ||
CEA | < 0.001 | < 0.001 | ||||
Negative | 1 | 1 | ||||
Positive | 1.943 | 1.858–2.032 | 1.515 | 1.446–1.587 | ||
Marriage status | < 0.001 | < 0.001 | ||||
Married | 1 | 1 | ||||
Single | 1.318 | 1.220–1.423 | < 0.001 | 1.266 | 1.171–1.367 | < 0.001 |
Separated/divorced | 1.366 | 1.279–1.460 | < 0.001 | 1.394 | 1.304–1.491 | < 0.001 |
Widowed | 2.375 | 2.248–2.510 | < 0.001 | 1.756 | 1.654–1.865 | < 0.001 |