Fig. 2

Recurrence and aggressiveness of the glioma xenografts. a Recurrence of the glioma xenografts in relapse GBM (IDH^WT at its P3 passage). Star shows the primary xenografts. Arrow shows the recurrent xenograft tumor after the removal of primary xenografts. b The distant aggressiveness in PDXs (Anaplastic oligodendroglioma, IDH^MUT at its P3 passage). Stars show the primary xenografts. Arrows show the distant invasive xenografts from the corresponding xenografts