Fig. 7

Mutation of IDH in serial passages of the xenograft. Genetic mutations of IDH analysis indicates that 10 cases of the examined genetic mutations through the generations are precisely replicated in the corresponding xenograft tumors, with the exception of case 20180521 in the PDXs losing the R132H mutation. A low heterozygous G/A (11.7%) mutation in the tumor of Patient 20180521. Arrow shows the mutation from G to A